Reviewed by John M. Grohol, Psy.D. on May 28, 2012
Researchers report that an antipsychotic drug sometimes used to treat schizophrenia appears to influence cancer stem cells to differentiate into less threatening cell types.
Investigators believe the discovery will be followed with a clinical trial. The findings are reported in the journal Cell.
In the study, scientists analyzed hundreds of compounds in search of those that would selectively inhibit human cancer stem cells.?You have to find something that?s truly selective for cancer stem cells,? said Mickie Bhatia, lPh.D., lead author of the study from McMaster University. ?We?ve been working for some time and it?s hard to find that exact formula.?
The research represents a new approach for cancer intervention, a necessary approach as the survival of cancer patients is largely unchanged from 30 years ago.
The new approach for cancer targets rare and chemotherapy-resistant cancer stem cells. Unlike normal stem cells, cancer stem cells resist differentiating into stable, non-dividing cell types.
Bhatia?s team exploited this difference to simultaneously screen compounds for their activity against human cancer stem cells versus normal human stem cells.
By testing hundreds of compounds, they identified nearly 20 potential cancer stem cell specific drugs.
The one that appeared most promising is an antipsychotic drug, thioridazine, which combats the symptoms of schizophrenia by targeting dopamine receptors in the brain. But concerns about side effects of the drug, brand name Mellaril, have meant that far fewer people with schizophrenia are prescribed the drug than newer antipsychotic medications.
Researchers say thioridazine doesn?t appear to kill cancer stem cells, but rather encourages them to differentiate, thus exhausting the pool of self-renewing cells.
Investigators discovered thioridazine kills leukemia stem cells without affecting normal blood stem cells by comparing the proteins in leukemia versus normal blood cells.
Furthermore, leukemia cells, but not normal blood stem cells, express a dopamine receptor on their surfaces. This finding is supported by the discovery of dopamine receptors on some breast cancer stem cells.
?This gives us some explanation,? Bhatia said. It also suggests that dopamine receptors might serve as a biomarker for rare, tumor-initiating cells.
In light of the findings, Bhatia?s team is already planning for a clinical trial of the FDA-approved thioridazine in combination with standard anti-cancer drugs for adult acute myeloid leukemia.
?We?re excited about bringing this drug to patients,? Bhatia said. ?We also hope our platform can now be a pipeline for other cancer stem cells drugs.?
Source: Cell Press
APA Reference
Nauert PhD, R. (2012). Drug Used for Schizophrenia May Check Cancer. Psych Central. Retrieved on May 30, 2012, from http://psychcentral.com/news/2012/05/28/drug-used-for-schizophrenia-may-check-cancer/39326.html
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Daniel Haszard comment-Thioridazine is in the class of 'typical' antipsychotics called phenothiazines of which 'Thorazine' is best known.This group is 50 years old and I have been taking Thorazine for 2 years for my PTSD to help me sleep.Continued research may show that it is the whole class of phenothiazines that have anti-cancer properties.
উত্তরমুছুন{"..researchers believe it will be safer for cancer patients because they’re only on it for eight to 21 days instead of a number of years, and they take half the dose..."
"..McMaster has since discovered schizophrenia patients who took the drug had 10 times fewer instances of cancer..."}
A cancer suppressive side effect of antipsychotic drugs would be a wonderful blessing.
A patient speaks:
There are two kinds of antipsychotics the 50 year old tried and tested inexpensive *typical* antipsychotics like Thorazine,and the newer so-called *atypicals* like Risperdal,Seroquel,Zyprexa.
These drugs are lifesavers for those with delusional mental illness which is only 1 percent of the population.
The saga of the so called *atypical antipsychotics* is one of incredible profit.Eli Lilly made $65 BILLION on Zyprexa franchise (*Viva Zyprexa* Lilly sales rep slogan).
Described as *the most successful drug in the history of neuroscience* the drugs at $12 pill are used by states to medicate deinstitutionalized mental patients to keep them out of the $500-$1,200 day hospitals.There is a whole underclass block of our society,including children in foster care that are the market for these drugs,but have little voice of protest if harmed by them.I am an exception,I got diabetes from Zyprexa as an off-label treatment for PTSD and I am not a mentally challenged victim so I post.
Google-Haszard Zyprexa
--Daniel Haszard - FMI http://www.zyprexa-victims.com