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সোমবার, ২৮ নভেম্বর, ২০১১
রবিবার, ২৭ নভেম্বর, ২০১১
Cambridge researchers translate graphene into printable circuitry material, bring basic 'Skynet' factory to you
Yes, graphene is amazing and possesses many useful / otherworldly properties. The ability to use graphene itself to print flexible, transparent thin-film transistors via an inkjet printer is just another one of them. Over at the University of Cambridge, researchers have discovered that it's possible to print standard CMOS transistors using a graphene component. Provided the graphene is chipped off a block of graphite using a chemical solvent and the larger (potentially print-head blocking) chips are removed, it can be turned into a polymer ink which can then run through a conventional inkjet printer. The potential result of this is flexible, transparent and wearable computer circuitry coming from ordinary printers as opposed to several multi-million-dollar machines in a factory, which has long been the historical standard. Besides, who wouldn't want to print their own circuitry on a PhotoSmart MFP rather than whatever report might be due the next day?
Cambridge researchers translate graphene into printable circuitry material, bring basic 'Skynet' factory to you originally appeared on Engadget on Fri, 25 Nov 2011 20:52:00 EDT. Please see our terms for use of feeds.
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শনিবার, ২৬ নভেম্বর, ২০১১
Kenneth downgraded to tropical storm in Pacific (AP)
MIAMI ? Forecasters say Kenneth is weakening rapidly and has been downgraded to a tropical storm in the eastern Pacific.
There is no threat to land from what had been the strongest late-season hurricane in that area on record when it earlier reached Category 4 status.
The U.S. National Hurricane Center in Miami said Thursday that Kenneth has maximum sustained winds near 60 mph (95 kph). The storm was centered about 945 miles (1,525 kilometers) southwest of the southern tip of Baja California, Mexico.
It is moving west-northwest at 10 mph (17 kph)
Kenneth is expected to weaken further. There are no coastal watches or warnings in effect.
The eastern Pacific hurricane season ends Nov. 30.
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Katy Perry to Play Marilyn Monroe on Broadway?
My Week With Marilyn just hit theaters, but producers of the Michelle Williams vehicle are already thinking about their next move for the late blond bombshell:
They want to take it to Broadway, with Katy Perry as the lead!
Producer Harvey Weinstein tells E! he wants to develop a Broadway musical based on the movie, which stars Michelle Williams as Monroe (see trailer below).
"If the movie works, I would try to make a musical and go to [Katy Perry] first. I think she can play Marilyn on the Broadway stage... I think she would be amazing."
Why? For one, Perry has become a cheerleader of sorts for the flick.
A remix of her hit "The One That Got Away" is being used in a new trailer for My Week With Marilyn. She's also got one heck of a musical following.
"Katy posted about it on Twitter and Facebook and the next thing you know 250,000 people have downloaded the trailer in an hour," Weinstein said.
Perry also did a recreation of Monroe for a video for "Teenage Dream" that was used for a 90-second commercial for German TV show Star Force.
What do you think? Could she pull it off?!
Source: http://www.thehollywoodgossip.com/2011/11/katy-perry-to-play-marilyn-monroe-on-broadway/
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শুক্রবার, ২৫ নভেম্বর, ২০১১
Egypt military rulers reject calls to step down
Egyptian Army soldiers stand guard atop a concrete block barricade on the street between Tahrir Square and the interior ministry in Cairo, Egypt, Thursday, Nov. 24, 2011. Police and protesters demanding that Egypt's ruling military council step down are observing a truce after five days of deadly street battles in which dozens have died. (AP Photo/Khalil Hamra)
Egyptian Army soldiers stand guard atop a concrete block barricade on the street between Tahrir Square and the interior ministry in Cairo, Egypt, Thursday, Nov. 24, 2011. Police and protesters demanding that Egypt's ruling military council step down are observing a truce after five days of deadly street battles in which dozens have died. (AP Photo/Khalil Hamra)
In this Sunday, Nov. 20, 2011 photo, an Egyptian riot police officer aims his rifle at a man near Tahrir Square in Cairo, Egypt. Police and protesters demanding that Egypt's ruling military council step down are observing a truce after five days of deadly street battles in which dozens have died. (AP Photo/Tahsin Bakr)
A boy looks at Egyptian Army soldiers standing guard atop a concrete block barricade on the street between Tahrir Square and the interior ministry in Cairo, Thursday, Nov. 24, 2011. Police and protesters demanding that Egypt's ruling military council step down are observing a truce after five days of deadly street battles in which dozens have died. (AP Photo/Khalil Hamra)
Protesters sleep in Tahrir Square in Cairo, Egypt, Thursday, Nov. 24, 2011. Police and protesters demanding that Egypt's ruling military council step down are observing a truce after five days of deadly street battles in which dozens have died. (AP Photo/Bernat Armangue)
A woman protester attempts to dismantle a barbed wire barricade, newly erected by the Egyptian army, near Tahrir square in Cairo, Egypt, Thursday, Nov. 24, 2011. International criticism of Egypt's military rulers is mounting after five days of clashes between police and protesters demanding the generals relinquish power immediately. (AP Photo/Tara Todras-Whitehill)
CAIRO (AP) ? Egypt's military rulers rejected protester demands for them to step down immediately and said Thursday they would start the first round of parliamentary elections on time next week, despite serious unrest in Cairo and other cities.
The ruling military council insisted it is not the same as the old regime it replaced, but the generals appear to be on much the same path that doomed Hosni Mubarak nine months ago ? responding to the current crisis by delivering speeches seen as arrogant, mixing concessions with threats and using brutal force.
So far it's working no better than it did under the former leader.
Protesters in Cairo's Tahrir Square, seething over the military's perceived failings over the past nine months, say they will not leave the iconic plaza until the generals step down in favor of a civilian presidential council, a show of resolve similar to that which forced Mubarak to give up power in February after nearly three decades.
"What we want to hear is when they are leaving," said Tahrir protester Khaled Mahmoud on hearing of an apology offered by the military for the deaths of nearly 40 protesters since Saturday. "The ouster of the marshal is only a matter of time," he added, referring to Field Marshal Hussein Tantawi, who was Mubarak's defense minister for 20 years before he succeeded him in February.
"There will be no postponement in the election," said Maj. Gen. Mamdouh Shaheen, one of two members of the ruling military council who spoke at a televised news conference on Thursday. "The election will be held on time with all of its three stages on schedule."
The two generals said the throngs in Tahrir do not represent the whole of Egypt and warned of chaos if the council was to immediately step down, language similar to Mubarak's scare-mongering while trying to cling to power in the face of the 18-day uprising against his rule.
The two generals ? Shaheen and Maj. Gen. Mukhtar el-Malla ? also said that parliamentary elections would start on time Monday and that a new prime minister to replace Essam Sharaf would be picked before the vote.
News reports that were not yet officially confirmed said Kamal el-Ganzouri, who served as prime minister under Mubarak in the 1990s, has been approached by the military as a possible candidate for prime minister. State television showed footage of el-Ganzouri meeting with Tantawi. If confirmed, el-Ganzouri would replace Essam Sharaf, whose government resigned this week.
Tahrir Square, meanwhile, was quieter Thursday after five days of intense clashes. Police and protesters agreed to a truce negotiated by Muslim clerics at the scene. At the same time, soldiers built barricades from metal bars and barbed wire to separate the protesters and the police on streets-turned-battlefields leading from Tahrir to the nearby Interior Ministry.
Protesters formed a series of human chains on the those streets to prevent anyone from violating the truce or approaching flashpoint areas close to the police lines. The truce came into force around 6 a.m. and was holding by nightfall.
The two generals from the ruling council who spoke attempted a revision of recent history to fend off calls for the military to step down.
They said their legitimate claim to power came when troops were warmly welcomed by Egyptians at the time they took over the streets from the discredited police early in the anti-Mubarak uprising. The legitimacy of their rule was reinforced by the overwhelming endorsement Egyptians gave to constitutional amendments they proposed and put to a referendum in March, they said.
"Consequently, it will be a betrayal of the people's trust if the military council was to relinquish power now," Shaheen said. "History will not kindly remember that."
El-Mallah, addressing the same news conference, said the military respected the views of the Tahrir protesters, but they did not represent the whole of Egypt.
"We will not relinquish power because a slogan-chanting crowd said so. ... Being in power is not a blessing. It is a curse. It's a very heavy responsibility."
Activists blame the military council for the country's persistently tenuous security and its growing economic woes, along with a host of other failings.
They say the council has been secretive, issuing cryptic decrees, cracking down on critics and seeking to discredit groups behind the anti-Mubarak uprising and turn the public against them. It has put at least 12,000 civilians on trial before military tribunals and is accused of torturing detainees.
The military's standing as the nation's most upright institution was dealt a heavy blow by clashes during a Coptic Christian protest on Oct. 9 in which 27 people died, most of them Christians. Video showed soldiers running down demonstrators with armored vehicles. The military tried to deny its troops opened fire or intentionally ran over protesters, blaming the violence on Christians and "hidden hands."
A coalition of more than 20 youth groups and political parties, responding to the comments made by Shaheen and el-Mallah, accused the military of spreading "misinformation" and pledged to continue their sit-in until it transfers power to a "national salvation" government to oversee elections for a new parliament and president.
"We are determined to protect our (January) revolution," they said in a statement that also disputed the assertion by the two generals that the March referendum gave legitimacy to the military's rule.
The military has been Egypt's most powerful institution since army officers seized power in a 1952 coup that toppled the monarchy. All four presidents since then hailed from military background. Taking the reins from Mubarak on Feb. 11 gave the military the opportunity to directly rule Egypt for the first time since the early 1950s, something that critics often cite to explain their political inexperience.
With Mubarak under arrest and being tried on crimes punishable by death, Tantawi and his generals would be loath to step down under pressure and leave themselves vulnerable to legal proceedings by the next administration. Additionally, stepping down would inflict lasting damage to the military's standing, although that has already been hurt by the scathing criticism and ridicule they already have endured on the streets and in the independent press.
Perhaps as a precaution against such a prospect, the generals have been trying to win immunity for the armed forces against civilian oversight and to enshrine a role for themselves in the next constitution as guardians of the nation. The bid was seen as one of the final straws that sent people out onto the streets again, convinced the military was trying to grab and cling to power.
The military has countered the criticism with implicit threats, frequently using the patriotism card and insisting that they have no wish to stay in power beyond the election of a new president before the end of June 2012.
"O glorious people of Egypt, our only loyalty in the armed forces is to you and the soil of Egypt," Tantawi told the nation this week in a televised address. "Criticism directed at the Supreme Council of the Armed Forces (the formal name of the military's ruling council) aims at weakening our will and mandate and seeks to undermine the great trust between the people and their armed forces," said Tantawi, whose address bore a striking resemblance to speeches given by Mubarak during the January-February uprising.
The two generals also praised the police for what they said was their restraint and said they have every right to defend themselves, but acknowledged they made mistakes while handling the protesters. They said nothing about witness reports that members of he military police also battled protesters alongside the hated police in the latest clashes.
They appeared to try to drive a wedge between the protesters, addressing those camping out in Tahrir square as "honorable" while criticizing others who battled the police for five days on nearby side streets.
The military, said the two generals, would return to their barracks if only Egyptians voted in favor of that move in a referendum or when an elected civilian administration was in place. The idea of holding a referendum on the military immediately stepping down was first floated by Tantawi on Tuesday.
The military's defiance in the face of popular opposition to its rule comes as more and more protesters in Cairo and elsewhere in Egypt blame the army and the much hated police equally for the death of nearly 40 protesters since the clashes broke out on Saturday. At least 2,000 others have been wounded. The military is also accused of remaining loyal to Mubarak, having put him under arrest and on trial only when large protests pressured them to do so.
"The army is now operating like the police, a tool of suppression," said protester Mayada Khalaf. "With all these lies from the army, it is like they are sticking their tongues out at us."
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বৃহস্পতিবার, ২৪ নভেম্বর, ২০১১
Man angry about food prices slaps Indian minister (AP)
NEW DELHI ? A man has slapped India's agriculture minister in the face, apparently to draw attention to rising food prices.
Sharad Pawar was talking to reporters at a political function Thursday when the man attacked him. TV news reports said the man was shouting slogans about rising food prices.
Television footage showed the man brandishing a knife as he was dragged away by security officials and Pawar's aides. CNN-IBN TV reported that he was detained by police.
Pawar was not seriously hurt.
Such incidents have become increasingly common in India, where ministers and other officials have had shoes thrown at them and their offices ransacked by angry citizens.
The incidents have usually been over political decisions, corruption and real or perceived injustices.
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Hope for muscle wasting disease
Tuesday, November 22, 2011
A health supplement used by bodybuilders could be the key to treating a life-threatening muscular dystrophy affecting hundreds of Australian children, new research shows.
The amino acid L-tyrosine had a "rapid and dramatic impact" on Nemaline Myopathy (NM) in laboratory tests on mice, significantly improving symptoms of the muscle-wasting disease, medical researchers from the University of New South Wales (UNSW) found.
Trials showed that consuming L-tyrosine could significantly improve muscle strength and mobility in NM, raising the possibility it also could be effective in a range of other muscle-wasting diseases. L-tyrosine is readily available in health food shops for less than $30 and is used as a body building supplement and as a memory booster.
There is currently no cure for NM (or Rod Myopathy) ? the most common congenital muscle disease ? which causes muscle weakness of varying severity in an estimated 500 Australian children.
Children with NM experience delayed motor development and weakness in the arms and legs, trunk, throat and face muscles. The condition can lead to difficulties breathing and moving and, in its severest form, can cause death.
A team of scientists led by Professor Edna Hardeman, from UNSW's Neuromuscular and Regenerative Medicine Unit, were able to test the efficacy of the supplement after creating ? for the first time ? a genetically modified mouse which display the same genetic changes found in children with NM.
"These mice and have a remarkably similar disease profile to the children, with many of the animals dying young," Professor Hardeman said.
After feeding the mice the L-tyrosine, the team observed improvements in muscle strength, increased mobility and a reduction in a range of muscle pathologies.
The findings will now be used as the basis for a clinical trial to test L-tyrosine's ability to alleviate symptoms in children.
"This is the first clear demonstration that L-tyrosine supplements can significantly reduce both the clinical and pathological features of NM," Professor Hardeman said.
"L-tyrosine is readily available, it is easy to administer and our data suggest that long-term use is relatively safe," Professor Hardeman said.
"What's more, the rapid and dramatic impact of L-tyrosine in NM mice also raises the possibility the supplement may be beneficial for dystrophy patients and other muscle degenerative conditions."
###
University of New South Wales: http://www.unsw.edu.au
Thanks to University of New South Wales for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/115390/Hope_for_muscle_wasting_disease
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বুধবার, ২৩ নভেম্বর, ২০১১
Obama: I'm tax-cutter, Republicans should agree
President Barack Obama shakes hands after an address where he remarked on the American Jobs Act, Tuesday, Nov. 22, 2011, at Central High School in Manchester, N.H. (AP Photo/Charles Krupa)
President Barack Obama shakes hands after an address where he remarked on the American Jobs Act, Tuesday, Nov. 22, 2011, at Central High School in Manchester, N.H. (AP Photo/Charles Krupa)
Audience members listen as President Barack Obama speaks about jobs, Tuesday, Nov. 22, 2011, at Manchester High School Central in Manchester, N.H. (AP Photo/Charles Dharapak)
President Barack Obama speaks about jobs, Tuesday, Nov. 22, 2011, at Manchester High School Central in Manchester, N.H. (AP Photo/Charles Dharapak)
A protester, wearing glasses, smiles as he hands President Barack Obama a note as the president greeted audience members after speaking about jobs, Tuesday, Nov. 22, 2011, at Manchester High School Central in Manchester, N.H. (AP Photo/Charles Dharapak)
MANCHESTER, New Hampshire (AP) ? President Barack Obama sought to steal the spotlight from Republican presidential candidates Tuesday, challenging opposition lawmakers back in Washington to stand by their anti-tax pledges on one big measure.
Speaking in politically crucial New Hampshire, the state that is home to the nation's first presidential primary, Obama urged Congress to extend a Social Security payroll tax cut due to expire next month.
In effect, he dared Republicans ? many of whom have signed anti-tax pledges ? to vote against an extension, a move the White House says would lead to a $1,000 tax hike on a family making $50,000 a year.
If lawmakers vote "no, your taxes go up. Yes, you get a tax cut," Obama told the crowd. "Which way do you think Congress should vote?"
"Don't be a Grinch. Don't vote to raise taxes on working Americans during the holidays," he said during his speech at a Manchester high school.
Much of Obama's stop in Manchester was about trying to gain a foothold for his economic message in New Hampshire to balance the anti-Obama rhetoric from the Republican candidates swarming the state ahead of the Jan. 10 presidential primary. Obama's trip came on the same day that the Republican contenders were gathering in Washington for a foreign policy debate sure to focus on what they see as the president's failings.
In New Hampshire, he was greeted with a blunt message from Republican contender Mitt Romney, who bought campaign ads telling Obama, "Your policies have failed."
In his first trip to New Hampshire in nearly two years, the president was confronted by a state that has shifted sharply to the right since his victory here in the 2008 election. The state's crucial independent voters sided solidly with Republicans in the 2010 midterms, and recent polls suggest Obama would lose to Romney by 10 percentage points here if the election were held today.
Democrats had hoped to tuck the payroll tax extension, as well as a renewal of jobless benefits, into an agreement from the congressional deficit-reduction supercommittee. But with that option off the table following the committee's collapse Monday, the White House plans to make a full-court press for a separate measure to extend the tax cuts before they expire at the end of the year ? and set up Republicans as scapegoats if that doesn't happen.
Obama came face to face with the frustration of some New Hampshire voters, who are fed up with a local economy that is struggling to grow and increasingly unhappy with the president's leadership.
A group of protesters outside Manchester Central High School carried signs that read "Obama Isn't Working." And the president's speech was interrupted by a handful of people venting the frustrations of the Occupy Wall Street movement that has spread across to a number of cities.
Romney used Obama's trip as an opportunity to air his first 2012 television ads in the Granite State, and they were sharply critical of Obama's economic record. He also ran ads in New Hampshire newspapers that said to Obama, "I will be blunt. Your policies have failed."
While the White House insisted the president's stop was not about politics, the trip had a campaign feel, from the packed high school gymnasium where Obama spoke to the local restaurant where he dropped by to have lunch with a New Hampshire family.
The White House sees a year-end debate over extending payroll tax cuts, as well as renewing jobless benefits, as an opportunity to draw a distinction for voters between the president's priorities and those of Republicans. Economists have warned that letting both programs expire could be harmful to an economy still struggling to recover from recession.
The Republican field is not unanimous on whether to extend the payroll tax cut. Romney has said he's not for raising taxes "anywhere," and former House Speaker Newt Gingrich says that given the economic conditions "it's very hard to say no." In Congress, Rep. Michelle Bachmann voted against the payroll tax cut, but Rep. Ron Paul supported it. Businessman Herman Cain and Texas Gov. Rick Perry oppose extending the cut.
Last year's cut in the 6.2 percent payroll tax, which raises money for Social Security, was accomplished with borrowed money. This time around, administration officials say the president may not insist on the cuts being paid for immediately.
The 2 percentage-point cut in the 6.2 percent payroll tax gave 121 million families a tax reduction averaging $934 last year at a total cost of about $120 billion, according to the Tax Policy Center.
Obama also wants to cut the payroll tax by another percentage point for workers and cut the employer share of the tax in half as well for most companies.
___
Associated Press writers Julie Pace, Steve Peoples and Holly Ramer contributed to this report.
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Seattle Mariners outfielder Greg Halman slain
ROTTERDAM, Netherlands (AP) ? Dutch police say Seattle Mariners outfielder Greg Halman has been stabbed to death and his brother has been arrested as a suspect.
Rotterdam Police spokeswoman Patricia Wessels says police were called to a home in the Dutch port city early Monday morning and found Halman bleeding from a stab wound.
The officers attempted unsuccessfully to resuscitate the 24-year-old.
Wessels says the officers arrested Halman's 22-year-old brother. She declined to give his name, in line with Dutch privacy rules.
She said the brother was being questioned by police.
The Dutch-born Halman appeared in 44 games over the last two seasons for Seattle. He hit .207 with two homers and six RBIs.
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Future prostate cancer treatments might be guided by math
Tuesday, November 22, 2011
Scientists have designed a first draft of a mathematical model that someday could guide treatment decisions for advanced prostate cancer, in part by helping doctors predict how individual patients will respond to therapy based on the biology of their tumors.
These decisions would apply to treatment of cancer that has already spread beyond the prostate gland or that has recurred after initial treatments, such as surgery or radiation. Patients with this more advanced prostate cancer receive a therapy called androgen ablation, which inhibits production of testosterone ? the culprit that allows a tumor to keep growing.
Though the model's outcomes remain theoretical at this point, the researchers have developed enough of a system to show that their incorporation of some personalized data ? details about a patient's tumor cell characteristics in particular ? would give doctors more than they currently have to work with in making decisions about this stage of treatment.
"The model in its current form is proof of the concept that we can capture all of these different outcomes that are observed clinically. But we still need to refine the model with as much individual data as we can obtain," said Harsh Jain, a postdoctoral fellow in Ohio State University's Mathematical Biosciences Institute and lead author of the study.
"We envision that this model would be useful for clinicians who could keep feeding the equations with data about how a patient is responding to therapy, which would offer clues about how his cancer cells are mutating. Once you have an idea about that for the short or medium term, the model could predict the optimal therapy for that patient," Jain said.
The model is described this week in the online early edition of the Proceedings of the National Academy of Sciences. Jain conducted the work with co-authors Steven Clinton, professor, and Arvinder Bhinder, assistant professor-clinical, in Ohio State's division of medical oncology, and Avner Friedman, a Distinguished University Professor at Ohio State.
Prostate cancer is diagnosed in about 240,000 American men and leads to about 34,000 deaths each year, according to the National Cancer Institute.
The treatment of this cancer in its more advanced stages brings about chemical castration by targeting one of several mechanisms involved in the production of testosterone. In most patients, cancer cells develop castration resistance over time ? on average, between 1? and two years after the start of treatment. However, the overall range of resistance development spans from a few months to more than 10 years.
Jain said that some scientists have proposed that this treatment leads directly to castrate-resistant disease because once testosterone is removed from the body, mutant cancer cells that can survive in a no- or low-testosterone environment are able to take over the tumor.
Currently, continuous treatment to eliminate testosterone is the standard of care. But because clinicians know castration resistance is inevitable, a new approach is under study. A national clinical trial is assessing the benefits and risks of intermittent androgen ablation ? keeping patients on the drugs until symptoms improve, and then giving men time off from the medication until the disease begins to progress again.
The math model developed by Ohio State scientists suggests that based on average clinical data currently available, such intermittent therapy could actually accelerate the development of castration resistance.
"In the same way that intermittent use of antibiotics gives a chance for bacteria that are resistant to the drug to take over, you might actually end up with intermittent anti-androgen therapy even more positively selecting for mutating cancer cells," Jain said.
However, the averages don't always apply, which is why the scientists are pursuing a system of differential equations to account for individual differences. For example, the "normal" levels of prostate-specific antigen, or PSA, in men's blood cover a fairly broad range, Jain noted. Yet the PSA test remains the most common screening method for prostate cancer, and is used to gauge the effectiveness of treatments in advanced stages, as well.
"The PSA ranges are massive. It's a very heterogeneous thing," Jain said. "When we are talking about cancer, our point is that those variables should be personalized. Everyone's cancer grows differently.
"There are a lot of questions. If you take an intermittent therapy route, how do you decide the scheduling of treatment? Is it based solely on PSA levels? Shouldn't there be some incorporation of personal patient characteristics into these treatment decisions? Can you identify a subgroup of patients who are predicted to respond well to this, or are there conditions when one treatment vs. another could actually make things worse?"
Math offers some answers. The model's foundation is based on existing animal and human data on prostate cancer characteristics. Beyond that, the researchers have selected parameters to plug into the equations that more specifically detail what could be going on in an individual tumor: cancer cell growth rates, cancer cell death rates, the level of activation of PSA in tumor cells, and how quickly one person's PSA can travel from the prostate to the bloodstream.
The scientists even took into account the competitive power of individual types of cancer cells ? for example, some mutated cancer cells aren't as strong as their normal cancer cell counterparts. In those cases, the math model predicts, the best treatment option would be intermittent therapy because the stronger normal cancer cells would keep mutant cells in check during time off from the medication. With the cancer consistently dominated by cells that rely on the presence of testosterone, the treatment would continue to target those stronger cells that respond to androgen ablation therapy, Jain explained.
"That's an important question with any therapy ? is it making things better or worse in terms of allowing mutated cells to take over?" he said.
Jain and colleagues are now working to boost the model's power by adding parameters that account for the blood vessel architecture in prostate tumors, a major indicator of how persistent the cancer will be. They also plan to add hundreds of individual patients' case study data to make its predictions even more authentic.
###
Ohio State University: http://researchnews.osu.edu
Thanks to Ohio State University for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
This press release has been viewed 43 time(s).
Source: http://www.labspaces.net/115387/Future_prostate_cancer_treatments_might_be_guided_by_math
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মঙ্গলবার, ২২ নভেম্বর, ২০১১
Winners and Losers of the Deficit Supercommittee Deadlock (Time.com)
Jim Lo Scalzo / EPA
Democratic Senate Majority Leader from Nevada Harry Reid talks to reporters about Supercommittee negotiations after the Democrat's weekly leadership lunch in Washington, Nov. 8, 2011.
With the deficit supercommittee charged with finding $1.2 trillion in savings teetering on the brink of failure, Washington is embroiled in a high stakes round of recriminations. Depending on whom you listen to, everyone?s to blame and everyone?s blameless. Three months closer to an election year, Congress is proving every bit as dysfunctional as it was during the debt ceiling deal that created the supercommittee in August, and looming primaries ? both presidential and congressional ? have put bipartisan compromise even farther out of reach. Really, there should be no shock that the committee has failed ? there were too many people who stood to benefit from its demise.
(MORE: In a Tea Party Universe, Visions of Supercommittee Success)
Congressional incumbents: If you?re, say, Senator Jon Tester, a Montana Democrat who has a tough reelection test ahead of him next November, what incentive would you have to vote for entitlement cuts, which would risk the support Native American tribes, seniors, lower income voters ? the trifecta of constituents that are pivotal to winning statewide in Montana. On the flip side, if you?re, say, Rep. Paul Gosar, an Arizona Republican freshman of the Tea Party persuasion, voting for increased revenue could leave you open not just to a primary challenge, but also vulnerable to a conservative Democrat in the general election. Ultimately, the political calculus was against any deal, and any member of Congress facing a close race can breathe a sigh of relief now that the supercommittee has deadlocked.
Congressional challengers: That said, new candidates for office have also been given a gift. Congress?s approval rating is near record lows and the supercommittee?s failure only serves to underline the hamstrung legislative process and the fact that those in office right now probably aren?t the ones who are going to fix it.
Democrats: As I noted?the day after the debt ceiling agreement, that deal wasn?t terrible for Democrats. Not only did they settle the 2012 budget with just $7 billion in non-defense discretionary cuts, but the likelihood of a supercommittee deadlock all but assured that Congress would pass tax reform in late 2012 or at the beginning of 2013. Democrats have long sought to raise revenue through tax reform without having to cut entitlement benefits, and now they will likely get their wish. The consequence of the supercommittee?s failure is that $1.2 trillion in cuts will automatically happen in January 2013, not coincidentally at the same time George W. Bush?s tax cuts expire. Those two events will create powerful incentives for tax reform.
(MORE: Amid Supercommittee Wranlging, Tax Reform Gains Momentum)
President Obama: On his tour of Asia, Obama wisely stayed about as far away as he could get from the supercommittee train wreck. After getting burned by being too close to the debt ceiling negotiations, Obama learned his lesson and let Congress embarrass itself. The supercommittee?s failure to reach an agreement only helps his strategy of running against Congress, as Harry Truman did in 1948. Now, he can spend the next year blaming congressional dysfunction for the country?s woes.
Americans for Tax Reform?s Grover Norquist: The deadlock proves his power to hold GOP politicians to his anti-tax pledge is as potent as ever. For all the stories about how Norquist was done and how lawmakers were finding ways around it, Republicans? fear of raising new revenue and crossing Norquist was one of the biggest contributing factors to the committee?s failure.
(MORE: When Grover Norquist Says ?Jump??)
Still, the supercommittee?s impending failure will not be without its casualties.
House freshmen: Whether this debacle was their fault or not, the new, largely Republicans class elected in 2010 has come to represent the congressional logjam and they are suffering for it. They are already running into fundraising trouble?and House Democrats outraised their GOP counterparts nearly two-to-one last month. Passing a bipartisan deal that satisfied the markets and reduced the deficit could?ve done wonders to reform their obstructionist image. Alas, it was not to be. So, while running for reelection having raised taxes would?ve been hard, this group is doubly screwed as they also bear the blunt of the blame for the sorry state of affairs.
The American people: Deficits remain a great threat to national security, as Mike Mullen, former chairman of the Joint Chiefs of Staff, once put it. The committee?s failure risks a stock market dive amid a widening European crisis and another potential downgrade of America?s bond rating status. Small business lending could get tougher?because of this debacle, the recession could drag out and unemployment could continue to stagnate. There are probably a dozen more winners and losers that I could name on the political spectrum. But the fact of the matter is, whatever short-term political gains anyone gets out of this, in the long run the American people lose.
(MORE: The Generational Divide That Will Define 2012)
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সোমবার, ২১ নভেম্বর, ২০১১
Ghost Incognito Automates Your Private Browsing [Chrome Extensions]
Chrome: Even though every browser has a private mode, it's not always easy to remember to enable it before visiting private sites. Ghost Incognito makes it so you don't have to by automatically opening sites of your choosing in incognito mode.
For most of your browsing experience, the icon sits unobtrusively on your tool bar. When you visit a site you don't want to keep a cache of for whatever reason, you click the icon and it opens in incognito mode. After using it once, it's stored, so every future visit does the same thing. It's a handy feature to have for sites like your bank, but with holiday shopping in full swing, it might work well to cover your tracks if you're ordering from a single retailer.
Ghost Incognito | Chrome Web Store via gHacks
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A Credit Crisis in China's Most Enterprising City Is Making the Country Nervous (Time.com)
Wenzhou is known for making shoes, buttons, eyeglasses, electric switches, water valves and 70% of the world's cigarette lighters. But its most famous product is entrepreneurs. Hemmed in by mountains and with little arable land, this city on China's southeastern coast has relied on trade for centuries. Even in the Maoist era, when capitalism came under sustained and violent attack, private enterprise was never entirely extinguished there. So after China began market reforms in the late 1970s, Wenzhou flourished. "The Wenzhou Model" of small, low-cost manufacturing operations was widely copied in China. Wenzhou now has some 140,000 companies, and its businessfolk have invested across the country in everything from real estate to mining. The city is the locus and symbol of private enterprise in China.
But in recent weeks, the reputation of Wenzhou's entrepreneurs has taken a serious hit. Dozens of factory bosses have fled bad debts, and at least two have committed suicide. Part of the cause is the challenging operating environment for manufacturers. Demand from export markets like the U.S. and Europe is weak, wage and materials costs at home are rising, and China's currency, the renminbi, has been steadily appreciating, making Chinese goods more expensive abroad. "Orders have been down this year and last ? that causes a lot of pressure," says Cai Jianguo. He started his Wenzhou eyeglass company, Zhengshi Optical, with just $1,200 and eight employees in 1997. Today he has more than 100 employees churning out some 30,000 pairs of plastic frames a month, mostly for export. But he's feeling the pinch. "For small businesses like ourselves, survival itself is a big challenge." (See portraits of Chinese workers.)
The main cause of Wenzhou's ills is far more explosive, however, and lies in the local tradition of private lending. Because Chinese banks prefer to lend to larger, state-owned enterprises that are ultimately backed by the central government, Wenzhou's entrepreneurs have long turned to one another for financing. "Private lending and private enterprises are a natural couple," says Hu Zhenhua, a professor of economics at Wenzhou University. "One cannot exist without the other."
That relationship has come under extreme strain. The central government's efforts to control inflation over the past year have restricted bank credit, driving up the demand for underground loans even more. In Wenzhou, local investors, including a significant share of the town's businesses, have been chasing hefty earnings through making private loans that have interest rates as high as 60%. But such levels of return are unsustainable, and over the past month the credit market has collapsed. In a town where almost everyone has lent or borrowed through the informal networks, the pain has been severe. Wenzhou entrepreneurs' ability to access nonbank credit may have been one of the sources of the city's success, but it now threatens to bring the local economy down. And given the extent to which local entrepreneurs have invested throughout China, the shocks will likely be felt nationwide. Shanghai Daily calls the Wenzhou meltdown "China's subprime crisis." (Read "The End of Cheap Labor in China.")
Not Just Kids' Stuff
Cai's anxieties about slim margins in the eyeglass business are almost mundane compared with those of another Wenzhou entrepreneur known as the Kid. (For his safety, he asked that his real name and some identifying details not be divulged.) The Kid is a private moneylender. Some would call him a loan shark. He pools money from local investors and loans it out to businesses that need cash. He started lending in 2007 with about $1 million of his own, bank loans against family property and money from hundreds of investors. A year later, when the global financial crisis hit, the Chinese government initiated a $586 billion economic-stimulus package and ordered banks to flood the market with credit, all in an effort ? ultimately successful ? to keep the domestic economy humming. But even amid that sea of credit, SMEs in places like Wenzhou still found it difficult to get bank loans because state enterprises were soaking up most of the money. For private firms, the stimulus was "like the rain that never reached the land ? it was intercepted in midair," the Kid says. "So the land had to draw water from underground."
That underground supply did not come cheap. The Kid made loans at 2.5% monthly interest, or about 34.5% annualized, far higher than the 7% to 8% charged to those getting bank loans. Things really took off for him over the past year as the central government tightened credit, raising benchmark interest rates and upping banks' reserve requirements. "You've got an environment where growth for the past few years has been driven by almost limitless easy credit," says Patrick Chovanec, an associate professor at Tsinghua University's School of Economics and Management in Beijing. "When the People's Bank of China began to impose limits on credit in order to rein in inflation, that demand for limitless credit as a driver of GDP growth didn't go away." Rather than squelching the demand for credit, those actions shifted it to the informal market.
See photos of China's 90 years of communism.
For a while, business was very good for the Kid. His fund grew to $15 million at its peak. Borrowers were paying back their debts quickly. In one week in May, for instance, the Kid took in nearly $8 million in repaid loans and interest. Many of the borrowers were small-scale real estate developers who needed money to fund projects ? but that's precisely why the Kid and others like him face problems now. Continued economic uncertainties and tighter mortgage policies have made property buyers increasingly cautious, and real estate sales have slowed dramatically. The people of Wenzhou "plowed their money into high-interest loans," says Victor Shih, a political scientist at Chicago's Northwestern University who studies China's financial system. "That was unsustainable because the high-interest loans went back into real estate projects. Eventually all of them will go bust."
For Wenzhou exporters facing ever narrowing margins, the temptation to put money into high-interest, informal syndicated loans has been especially high. Cai, the eyeglassmaker, resisted. "I never wanted that kind of money," he says. "It was too dangerous." But many others went ahead. The government estimated earlier this year that 60% of Wenzhou businesses and an astonishing 90% of households were involved in some form of private lending. Problems began to really emerge in late summer, when some large borrowers stopped repaying. In September, Hu Fulin, president of Xintai Group, another eyeglass manufacturer, fled to the U.S. to escape some $300 million in debts. He has since returned, but the situation remains dire ? some 90 other company heads have absconded. (See TIME's special report "China's Century [EM] or India's?")
The Kid collected about $3 million in August and early September, but says he recovered a mere $50,000 between late September and late October. "Everyone is hoarding money," he says. "Once they get it back, nobody lends it out again ? not even to their closest friends." The Wenzhou bubble has burst.
Surface Calm
Everything appears normal in Wenzhou. The streets leading from the city center to the surrounding factory districts are jammed as usual with trucks and delivery vans, new Range Rovers and dilapidated Citroen taxis. Beneath the surface, however, a mad race to collect debts is under way. For much of October, the Kid says he slept only two or three hours a night as he pondered how to claw back outstanding loans. "If people could get their money back just by holding other people at gunpoint, there would have been a riot in Wenzhou," he says. "It seems calm on the surface, but the chaos is underneath." In early October, Chinese Premier Wen Jiabao visited Wenzhou, where he ordered local banks to lend more and promised a crackdown on abusive underground lending. The local government has organized a $160 million fund to help overstretched businesses, and the fund is likely to grow.
The big issue, says Professor Hu, is what happens in January, ahead of the Chinese New Year, when Wenzhou's private lenders traditionally call in their outstanding loans. To come up with cash, indebted locals may unload real estate at discounted rates, which could truly burst the property bubble not just at home but also in Shanghai, Beijing and other cities where they have invested. "Should the liquidity chain in Wenzhou collapse to spark either sell-offs in the property market or the cutoff of liquidity for manufacturing or mining, this local crisis could evolve into a national problem," Xianfang Ren, Beijing-based senior economist for consultancy IHS Global Insight, wrote in mid-October. (Read "The China Effect.")
Still, Wenzhou accounts for just 1% of China's GDP. Manufacturer Cai says he plans to keep on churning out eyeglass frames, despite his ever tightening margins. "What else would I do?" he asks. And the Kid, if he can ever climb out of the massive hole he's dug, says he'll continue too. "When the market recovers, I'll still be willing to put 30% of my assets in private lending," he says. "If a Wenzhou person has 10 million renminbi, he wouldn't deposit it all in the bank. He'd at least spend 3.5 million on some kind of investment. Wenzhou people aren't stupid." The rest of China fervently hopes so.
? with reporting by Jessie Jiang / Wenzhou
See photos of China's infrastructure boom.
See TIME's Pictures of the Week.
View this article on Time.com
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রবিবার, ২০ নভেম্বর, ২০১১
[OOC] The Key
Forum rules
This forum is for OOC discussion about existing roleplays.
This forum is for OOC discussion about existing roleplays.
Please post all "Players Wanted" threads in the Roleplayers Wanted forum!
This topic is an Out Of Character part of the roleplay, ?Adenovirus 423?. Anything posted here will also show up there.Topic Tags:
Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.This thread is for me to post in only. I will state who the information is for and while all users can read it, only characters for that specific area will know the information unless stated otherwise. :)
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CriminalMinds - Member for 2 years
SOUTH: Documents that Adem had found
Day 50, sometime in the evening - No Man's Land,
I've been getting sicker. I've been coughing up blood the last few hours so my time is near. I'm convinced even more now that the Key and the Cure are in the form of a living being. I'm not sure how, or why, or who, but all the evidence I've collected gives me hope that I'm closer to a breakthrough. It's most likely too late for me, but if I can break through and lead someone to the Key, there will be hope for the rest of us.
Si.
Day 54, early hours of the morning - No Man's Land,
The Key has to be someone out here. All the evidence points to it. I haven't figured out how someone can be the cure, but I have a few theories:
1. They are immune to the virus.
2. They are a carrier of the non-virus and their offspring could be immune.
3. Something in the blood offers immunity.
Hopefully we find out who the Key is before it's too late. If option 2 is true, we will have to find them and get them procreating before they die due to the virus.
Si.
Day 61, mid-afternoon - No Man's Land,
I found a map today while scouring through some old ruins. It looks like someone else has been keeping record of their journey in what is now called 'No Man's Land'. The map is old though, it was just after the terrain had become dessert like after the war. It doesn't state though how 'No Man's Land' came to be. Why no one has claimed the area for themselves. Maybe this will be another war to fight once the Key has been obtained.
I'm afraid that if my predictions are right and the Key is a human, that ethics will come into play. Will they be killed for the cure, would they cooperate? What about the different factions? Who would get to her first? It is a hard thing to come by to make sure the outcome is right for everyone.
Ideally having the East or the West find this Key would be best. After all, they want what is best for everyone. North and South would take over and control everyone and everything if they found it. Not to mention what the Underground would do...
I have found an area on the map - two in fact that could be important. A place that was known as Arlington's Library, North of Loki's Kin. This could still have documents that haven't been raided and that have survived through the war. I have also found a black pentagon shape that has been circled but I have found no information about this.
Tomorrow I will make my way there.
Si.
Day 89, the black pentagon - Sometime after Midnight - No Man's Land,
I have found what I've been looking for! The Key! I know who it is. I just don't know where to find her. The documents here are amazing. If only...
The documents include the map. Each diary entry is on a separate piece of paper. It is also obvious that a lot of documents are missing. Has Adem hidden them somewhere else? The last diary entry trails off. Dried blood is on the page. Something sinister or did the virus take hold?
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CriminalMinds - Member for 2 years
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শনিবার, ১৯ নভেম্বর, ২০১১
'X Factor' Loses Stacy Francis As Astro Loses His Cool
'I don't want to perform for people who don't want me here,' mini-MC says after landing in the bottom two.
By Adam Graham
Stacy Francis on "X Factor"
Photo: FOX
Stacy Francis — the 42-year-old diva who once pleaded to Simon Cowell, "I don't want to die with this music in me!" — was eliminated from "The X Factor" Thursday night (November 17). But the bigger story was 15-year-old hip-hop dynamo Astro, who found himself in the bottom two with Francis and was none too pleased with his fate.
Asked to sing for his life in front of the judges, Astro nonchalantly strolled onto the stage and announced, "I really don't wanna perform. I feel like it's unnecessary." He turned to his mentor, L.A. Reid: "But I'mma leave it up to you. You're my mentor. Do you think I should I perform?"
Reid told Astro he had come a long way in the competition and that he should perform. Astro turned back and proceeded to give a halfhearted, visibly jaded performance of a song in which he talked about his experiences on the show. Francis, for her song, belted out "Amazing Grace."
When it came time for the judges to make their decision, Astro was scolded for his attitude by the panel, with Reid telling him, "You acted a little bit like a quitter, and it upset me." But Cowell was the hardest on the Brooklyn MC — whom Rihanna once compared to "a mini J. Cole" — telling him, "I don't like your attitude right now."
"Look at me, and think about your mum watching the show," Cowell said to him. "Because you are showing disrespect to your mom. You are showing disrespect to the audience at home, and I don't like people with this attitude."
Astro retorted, "No disrespect to you or this show, but I just feel like if you're going to put me in the bottom two, I don't want to perform for people who don't want me here, you know what I'm saying? That's it."
By this time, Astro was being showered with boos from the audience, and a tear that had welled up in his eye began to stream down his face. Cowell asked if he'd take the same attitude if put in the position again, and Astro apologized, telling him, "Honestly, man, it's cool."
With the audience chanting, "Stacy! Stacy!" Cowell cast his deciding vote. "I really don't want to do this," he said, voting for Astro to stay, saying he thinks he had a better chance of winning the show and ultimately sending Francis packing with a 3-1 vote in favor of her ouster. (Nicole Scherzinger, Francis' mentor, was the sole vote for her to remain.)
Francis thanked the judges for her time on the show and took responsibility for her so-so rendition of Meat Loaf's "It's All Coming Back to Me Now" the night prior, which was slammed by Cowell.
"I don't believe I did great last night. I go with that, and I have to suck up my pride and take responsibility for the performance I gave," Francis said. "I just want to thank Simon Cowell for giving me a chance, because I'm 42 years old, and he allowed me to sing for the world week to week."
Earlier in the night, Paula Abdul — who had already seen two of her groups get kicked off the show — caught a break when she learned her sole remaining group in the competition, Lakoda Rayne, was voted through to next week. Upon hearing the news, Cowell looked as though William Hung just won a Grammy, while Abdul proudly crowed, "I told you so, I told you so!" During the commercial break following the announcement, Cowell tweeted, "How the hell did that happen?"
The episode also featured a performance from Rihanna, who showcased her current Billboard chart-topping single "We Found Love." While it was presented as live, the performance was taped following Wednesday's episode.
The top 10 contestants opened the show with a group rendition of Queen's "We Will Rock You," celebrating the week's rock and roll theme.
What did you think of Astro's reaction to his near-elimination? Let us know in the comments!
Related PhotosSource: http://www.mtv.com/news/articles/1674624/x-factor-stacy-francis-astro.jhtml
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CBI raids Bharti, Vodafone offices (Reuters)
REUTERS ? The Central Bureau of Investigation (CBI) on Saturday conducted searches at Vodafone's Indian unit and Bharti Airtel's offices seeking details on spectrum allocation by the government to operators between 2001-02.
The searches were in regard to possible irregularities in allotting spectrum during the previous government led by the Bharatiya Janata Party (BJP), now in opposition, Central Bureau of Investigation's (CBI) spokeswoman, Dharini Mishra told Reuters.
"All our documents are in complete compliance with the governing laws and regulations. Vodafone India is completely co-operating with the officials and will provide them all the required details as part of their checks," Vodafone said in a statement.
The CBI conducted raids at Vodafone's Mumbai and New Delhi offices and Bharti Airtel's office in Gurgaon, near New Delhi.
"We would like to categorically state that all the spectrum allotted to us from time to time has been strictly as per the stated government policy," Bharti Airtel's spokesman said in a statement.
"We are providing all details and correspondence to the authorities and shall provide complete support as needed in the matter," Bharti Airtel's spokesperson said.
The Congress party-led government has been rocked by a series of corruption scandals that sparked massive street protests by anti-graft activists, sent prominent politicians to trial and undermined investor confidence in the Asian giant.
The biggest case involves the trial of business executives and the former telecoms minister, who is accused of taking bribes to favour some firms which wanted to buy mobile phone licences. The Comptroller and Auditor General of India (CAG) has said the under-selling of licences for kickbacks may have cost India $39 billion in revenue.
Saturday's searches could give the Congress party ammunition to fight back against the main opposition BJP's attacks against the government. Shouting matches and walkouts shut down parliament on a near daily basis for much of the year.
The BJP repeated past accusations that the CBI was under the tacit control of the Congress party. A BJP spokesman said the searches were carried out to deflect scrutiny away from the government's own corruption scandals.
"Now they are raking up this issue just to divert the attention," Prakash Javadekar, a BJP spokesperson told a press conference.
The Lokpal Bill will likely top the agenda when parliament reconvenes on Tuesday.
(Reporting by Siddesh Mayenkar in MUMBAI & Matthias Williams in NEW DELHI, Editing by Jonathan thatcher)
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